Insync probiotic review12/21/2023 ![]() The pathophysiology of IBS is not clearly understood, and it is suggested that the condition is multifactorial, affected by environmental, inherited, and psychosocial factors. Symptoms include bloating, flatulence, abdominal pain, or discomfort associated with a change in bowel habits (diarrhea, constipation, or mix). Irritable bowel syndrome (IBS) is a frequent functional gastrointestinal disorder (FGID), calculated to affect around 11.2% of the world’s population. Overall, the beneficial effects were more distinct in the trials using multi-strain supplements with an intervention of 8 weeks or more, suggesting that multi-strain probiotics supplemented over a period of time have the potential to improve IBS symptoms. Of note, three studies evaluated the effect of a mono-strain supplement, whereas the remaining eight trials used a multi-strain probiotic. Seven studies (63.6%) reported that supplementation with probiotics in IBS patients significantly improved symptoms compared to placebo, whereas the remaining four studies (36.4%) did not report any significant improvement in symptoms after probiotic supplementation. ![]() The search identified in total 35 studies, of which 11 met the inclusion criteria and were included in the systematic review. RCTs published within the last five years evaluating effects of probiotic supplements on IBS symptoms were eligible. A literature search was conducted in Medline (PubMed) until March 2019. ![]() The aim of this systematic review was to assess the latest randomized controlled trials (RCTs) evaluating the effect of probiotic supplementation on symptoms in IBS patients. The exact mechanisms of probiotics in the human body are not fully understood, but probiotic supplements are thought to improve IBS symptoms through manipulation of the gut microbiota. Irritable bowel syndrome (IBS) is a frequent functional gastrointestinal disorder, and alterations in the gut microbiota composition contributes to symptom generation.
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